RABBIT ANTI RIBOSOMAL PROTEIN SA

Rabbit anti Human ribosomal protein SA antibody recognizes the 40S ribosomal protein SA, also known as 37/67 kDa laminin receptor, LBP/p40, colon carcinoma laminin-binding protein, lamR or LBP.

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. RPSA gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of RPSA exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for RPSA (provided by RefSeq, Jul 2008).

Rabbit anti Human ribosomal protein SA antibody detects a band of 38 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.