RABBIT ANTI PSMD3

Rabbit anti Human PSMD3 antibody recognizes PSMD3, also known as 26S proteasome non-ATPase regulatory subunit 3 and tissue specific transplantation antigen 2.

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The PSMD3 gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in PSMD3 are associated with neutrophil count (provided by RefSeq, Jul 2012).

Rabbit anti Human PSMD3 antibody detects a band of 61 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.