RABBIT ANTI NXF1

Rabbit anti Human NXF1 antibody recognizes NFX1, also known as mRNA export factor TAP and tip-associated protein.

The NXF1 gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family include a non-canonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows hetero-dimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleo-porins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in NXF1 family. The encoded protein of NXF1 shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants (provided by RefSeq, Jul 2008).

Rabbit anti Human NXF1 antibody detects a band of 70 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.