RABBIT ANTI MMP-3

Rabbit anti Human MMP-3 antibody recognizes matrix metalloproteinase 3 also known as proteoglycanase or transin-1.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The MMP3 gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3 (provided by RefSeq, Jul 2008).

Rabbit anti Human MMP-3 antibody detects a band of 60 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.