RABBIT ANTI INHIBIN BETA B

Rabbit anti Human inhibin beta B antibody recognizes inhibin beta B, also known as INHBB, activin AB beta polypeptide and activin beta-B chain.

The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extra-gonadal tissues may vary several fold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion (provided by RefSeq, Jul 2008).

Rabbit anti Human inhibin beta B antibody detects a band of 52 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.