RABBIT ANTI IGF1R

Rabbit anti Human IGF1R antibody recognizes the insulin-like growth factor 1 receptor, also known as IGF-I receptor, soluble IGF1R variant 1, IGFR or soluble IGF1R variant 2.

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival (provided by RefSeq, Jul 2008).

Rabbit anti Human IGF1R antibody detects a band of 95 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.