RABBIT ANTI hnRNP D

Rabbit anti Human hnRNP D antibody recognizes hnRNP D also known as heterogeneous nuclear ribonucleoprotein D0, ARE-binding protein AUFI, type A or AU-rich element RNA-binding protein 1.

hnRNP D belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by HNRNPD gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of HNRNPD results in four transcript variants (provided by RefSeq, Jul 2008).

Rabbit anti Human hnRNP D antibody detects a band of 37-48 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.