RABBIT ANTI HGF

Rabbit anti Human HGF antibody recognizes hepatocyte growth factor (HGF), also known as fibroblast-derived tumor cytotoxic factor, hepatopoeitin-A and lung fibroblast-derived mitogen.

HGF regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. HGF is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69 kDa alpha-chain and 34 kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of HGF produces multiple transcript variants encoding different isoforms (provided by RefSeq, Jul 2008).

Rabbit anti Human HGF antibody detects a band of 83 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.