RABBIT ANTI CAVEOLIN 1

Rabbit anti Human caveolin 1 antibody recognizes caveolin-1 also known as cell growth-inhibiting protein 32, CAV1, or PPH3 .

The scaffolding protein encoded by CAV1 is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene CAV1 is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in CAV1 have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1 (provided by RefSeq, Mar 2010).

Rabbit anti Human caveolin 1 antibody detects a band of 21 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.