RABBIT ANTI AMPK GAMMA 1

Rabbit anti Human AMPK gamma 1 antibody recognizes AMPK gamma 1 also known as 5'-AMP-activated protein kinase subunit gamma-1, PRKAG1 or AMPK gamma-1 chain.

The protein encoded by PRKAG1 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed (provided by RefSeq, Jul 2008).

Rabbit anti Human AMPK gamma 1 antibody detects a band of 35 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.