RABBIT ANTI 14-3-3 THETA

Rabbit anti Human 14-3-3 theta antibody recognizes the 14-3-3 protein theta, also known as 14-3-3 protein T-cell, 14-3-3 protein tau, 14-3-3 protein theta, or. tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide.

The YWHAQ gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. YWHAQ is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease (provided by RefSeq, Jul 2008).

Rabbit anti Human 14-3-3 theta antibody detects a band of 28 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.